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10.1002/iub.2046 44 ZhangL.LiP.TangZ.DouQ.FengB

They mimic the incretin hormone GLP-1 to improve glucose-dependent insulin secretion, delay gastric emptying, and reduce appetite, leading to significant weight loss and metabolic improvements [3]

ArticlePubMed 2

This includes those who: Have heart disease, kidney problems, or overweight Want to avoid weight gain or low blood sugar from other diabetes medicines People with overweight or obesity, including: Adults with a body mass index (BMI) of 30 or higher Adults with a BMI of 27 or higher and at least one weight-related health problem (such as high blood pressure or sleep apnea) Adults who have not met weight-loss goals with lifestyle changes alone Adolescents with obesity who qualify for certain GLP-1 medications Who should not receive GLP-1 medications

Diabetes Ther 16 , 813849 (2025)

Tirzepatide users were less likely to experience any major cardiovascular problems following surgery than people not on the drug (roughly 30% lower risk), though the rate of some problems like heart attacks remained roughly the same between the two groups