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FDA Approval for Weight Management The Approval Process: The U.S Food and Drug Administration (FDA) has approved tirzepatide, under the brand name Zepbound , specifically for long-term weight management in adults with obesity (BMI 30 kg/m) or overweight individuals (BMI 27 kg/m) who have at least one weight-related health condition
Positive cardiovascular outcomes would strengthen the case for dual agonism as a preferred therapeutic approach, particularly in high-risk patients

The inclusion of oral GLP-1s at $149/month could make these medications even more accessible for patients who prefer a pill over injections

Fasting hyperglycemia, a defining feature of T2DM, is caused by increased gluconeogenesis and increased hepatic glucose output
Other Common Side Effects of Mounjaro Mounjaro's side effect profile is predominantly characterised by gastrointestinal disturbances , which are consistent with the mechanism of action of GLP-1 and GIP receptor agonists