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The results in humans, however, were modest enough that it has not advanced to Phase 3 approval for any fat loss indication

The SELECT trial showed that semaglutide reduced major adverse cardiovascular events (heart attack, stroke, cardiovascular death) in adults with obesity and established cardiovascular disease, without requiring a diabetes diagnosis. The FLOW trial showed kidney benefits with semaglutide use in patients with type 2 diabetes and chronic kidney disease. Improvements in hard clinical outcomes like cardiac events, kidney disease, and death are commonly observed with GLP-1 use, and are due to both the direct effects of treating the obesity, and indirect effects of the medications themselves

Theyre not wrong, but heres the thing: The alternatives either disappeared or became unaffordable overnight

Gene Activation: The GCG gene directs the production of proglucagon (a precursor protein for GLP-1), while the PCSK1 gene produces enzymes that convert proglucagon into its active GLP-1 form

Beck RW, Connor CG, Mullen DM, et al

Occasional constipation is common and does not necessarily indicate an underlying health issue