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Doses listed as Available on the FDAs shortage list are backordered at pharmacies across the country Obesity rates are expected to exceed 50% in the majority of states by 2030 Patients with obesity have, on average, ~$2000 higher healthcare costs per year Obesity is associated with 8 out the 10 leading causes of death and 200 health complications There is a nationwide shortage of healthcare providers, with the problem only expected to worsen (50% are older than 55 years old) There is intense stigma associated with obesity and treatment for the condition in the media, healthcare, socially and professionally Access is unequal

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Nevertheless, GLP-1 presented a rather ephemeral circulatory half-life, lasting a mere 12 min, due to the rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which markedly limits its biological efficacy [3,4,5]

As an approved prescription medicine, semaglutide has been extensively studied in human trials under medical supervision

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