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While both are derived from proglucagon, GLP-1 is primarily used to study insulin secretion and appetite, whereas GLP-2 is used to study intestinal growth and repair

Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell

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Interestingly, the residues at multiple positions (12, 16, 17, 20, 21, 24 and 28) of the multi-targeting agonists are highly solvent-accessible and of limited contact with GLP-1R, allowing them to employ distinct amino acids from GLP-1 without altering GLP-1R signaling profiles