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The margin of error at that volume is massive relative to the intended dose

For pharmaceutical companies, compulsory licensing risk is a consideration in pricing and access strategy in emerging markets
Safe: The site typically has no critical structures nearby

Hot flushes may occur indirectly through weight loss-related hormonal changes, metabolic shifts, or glycaemic fluctuations rather than direct pharmacological action

References Gao, J

Noncovalent binding with albumin has been effectively employed to extend the half-life of peptides by attaching various ligands, such as fatty acids or antibody domains targeting albumin, known as AlbudAb, to the peptides or miniproteins
