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And eventually, it may be evidence payers, clinicians, employers, and patients all start asking for.

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These agents target multiple hormone pathways involved in appetite regulation, insulin secretion, energy expenditure, and hepatic metabolism

By exploring human studies and mechanistic insights, this review underscores irisins potential to address global health challenges, such as obesity and type 2 diabetes, while advancing strategies for personalized exercise interventions.

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Secondary outcomes were each of these events considered separately