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Endocrinology 1996, 137, 29682978
"Generally mild" doesn't mean insignificant
Muscle pain and body aches sometimes appear, especially at higher doses
RF-409 is not expected to be universally effective across all classes of IR mutations but is well suited to variants that retain receptor expression and intrinsic kinase activity while being defective in insulin binding or ligand-induced activation, as illustrated by the IR D707A mutation
This action helps in reducing appetite and can help promote significant weight loss as a result
[DOI] [PubMed] [Google Scholar] 6.Nauck MA, Meier JJ
