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GLP-1RAs should not be considered first-line therapy for overt HF, as they represent a valuable tool in the prevention and early modulation of HFpEF in patients with metabolic risk

Risk appears highest at the 2.4 mg dose

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Alternative options include optimised thyroid replacement, multicomponent lifestyle programmes, orlistat, or bariatric surgery for eligible patients

To make the walkthrough concrete, I am anchoring on Pomegranates actual flow, since it scored highest overall (94) and has the cleanest end-to-end experience I tested