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This twofold activation creates a synergistic effect: GLP-1 handles appetite suppression while GIP enhances insulin secretion and energy expenditure

Secondary outcomes included absolute change in body weight and weight circumference from 36 to 88 weeks, the percentage of adults achieving at least a 5%, 10%, 15%, 20% or 25% weight loss from baseline to 88 weeks and the percentage of adults that maintained at least 80% of the body weight they lost during the open-label period

The common condition occurs when the orbicularis oculi, a muscle that surrounds the eye and closes the eyelids, contracts involuntarily

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