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Compared to those receiving neither medication, all-cause mortality was significantly lower among patients treated with SGLT2-I only (HR 0.28, 95% CI 0.270.29), GLP-1RA only (HR 0.39, 95% CI 0.370.40) and both agents (HR 0.17, 95% CI 0.160.18)

Fatigue is reported by some patients using GLP-1 medications, but it's often temporary and manageable

Dose reduction was required in 12.5% of patients, mostly owing to gastrointestinal symptoms, and discontinuation for any reason occurred in 5.5%

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