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Long-Term Semaglutide Use: Safety and Efficacy Data Studies tracking patients on semaglutide for 23 years show sustained weight loss and stable metabolic improvements when the medication is continued

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Gastroenterology 152 , 17521764 (2017)

However, she continued, a recent paper showed that ablating the GLP1R-expressing neurons in the hindbrain dorsal vagal complex, including the nucleus of the solitary tract, blocks the ability of the systemic receptor agonist to suppress intake (Huang et al., 2024)

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