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(58) reported that GLP-1 receptor gene expression was detected in endometrial tumors and that expression was higher in lean mice and reduced by tirzepatide

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Food and Drug Administration, serves as a comprehensive repository for post-marketing surveillance data, systematically collecting and analyzing spontaneous adverse drug reaction reports from global sources

doi: 10.1016/j.cmet.2023.11.009 99 WongCKYustaBKoehlerJABaggioLLMcLeanBAMatthewsDet al

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Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or severe gastrointestinal conditions like gastroparesis may rule out tirzepatide and similar GLP-1 based therapies