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2025 Exhibit 157: Prices for Products Selected for 2026 Medicare Drug Price Negotiation Program, by Total and Out-of-Pocket Spending Exhibit 158: Quarterly Change in Specialty Drug Utilization, by Beneficiary Income, 2024 Exhibit 159: Number of Stand-Alone Medicare Part D Prescription Drug Plans, 2007 to 2026 Exhibit 160: Illustrative Effect of Inflation Reduction Act on Medicare Part B Margins, 340B Hospitals vs

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41 Appendage of the amino acid sequences of either cagrilintide or pramlintide to the C-terminus of semaglutide resulted in significantly diminished potency at the AMYR, with a 2050-fold decrease compared to cagrilintide