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In a study on people with obesity and asthma, researchers saw significant improvements in the asthma scores of people who had been on GLP-1 medications for a year.

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However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis