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This dual action helps normalize blood glucose with lower risk of hypoglycemia compared to some older diabetes medications, though the risk increases when combined with insulin or sulfonylureas

They will decide whether a medication is safe for you based on certain factors, such as other health conditions you have or medications you take

By activating the receptors for both GLP-1 and GIP, tirzepatide helps your body in several ways: Enhances insulin secretion in response to meals Reduces glucose production by the liver Slows stomach emptying, leading to increased feelings of fullness These combined effects help regulate blood sugar and curb appetite, making it easier for patients to reduce food intake and achieve sustainable weight loss

The goal is a safe, supported plan

Many people find it helpful to log injections, weight, food and protein intake, side effects, sleep, mood, and energy levels

Acknowledgements We are grateful to Shinji Sakai, Shinji Deguchi, Kana Furukawa for animal care