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tirzepatide and cardiovascular outcomes In a large real-world study, tirzepatide was associated with a lower incidence of major cardiovascular outcomes vs semaglutide: Composite CV outcome: 1.90% vs 2.18% (HR 0.86, p=0.01) New-onset heart

Semaglutide can influence how your body handles fluid balance, but the relationship between GLP-1 therapy and water retention is more nuanced than simple yes or no

In these cardiovascular safety trials, in secondary or exploratory analyses, GLP-1 receptor agonists were also shown to reduce macro-albuminuria, an accepted surrogate marker for diabetic kidney disease (DKD), a condition that still represents a major unmet medical need

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