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Closing this gap is itself a challenge for lifestyle treatment

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The reduction in circulating insulin levels that accompanies weight loss may promote visceral fat mobilization, as insulin normally promotes fat storage

The mechanisms that drive enteroendocrine release of these gut peptides into the blood stream are multifactorial and include responses to direct nutrient stimulation, intracellular metabolism, or neuroendocrine mechanisms [see Psichas, et al

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There is also evidence for mechanisms involving a reduction of neuroinflammation, an increase in synaptic functioning, as well as the restoration of brain pathways of insulin signaling that may lead to improved memory formation and therefore a positive effect in Alzheimers disease and Parkinsons disease, note the authors