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In the central nervous system, the action of GLP-1 and GLP-1RAs on its receptors can affect a variety of brain functions including satiety, thermogenesis, influence blood pressure, neurogenesis, neurodegeneration, retinal repair, and change energy homeostasis [16-20]

All GLP-1RAs [reviewed in (81)] and, more recently, the dual incretin receptor agonist tirzepatide, have been shown to lower postprandial triglyceride and ApoB-48 levels significantly (82)

Additionally, maintaining adequate hydration, avoiding prolonged starvation, and ensuring appropriate glucose and ketone monitoring are crucial

In more severe or urgent situations, such as with severe IIH, surgical intervention for weight loss is a possible treatment option

So far, it has demonstrated unparalleled efficacy in the treatment of T2DM accompanied with improved glycemic regulation [8, 9]

doi: 10.1016/j.cbi.2018.01.004