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For weight loss, the main options are Wegovy (semaglutide), Saxenda (liraglutide), and Mounjaro (tirzepatide)

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It seems in pre-clinical models that when these L-cells are exposed to perceived toxins, such as lipopolysaccharides from certain bacteria that this triggers a surge in endogenous GLP-1 which is perhaps the bodys way of using GLP-1 as an anti-inflammatory hormone or perhaps as a brake pedal on the inflammatory response in general

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This study showed a mean weight reduction of 10%, and significant reductions in triglyceride, total cholesterol, and LDL-C levels of 25%, 11%, and 11% respectively [32]