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This is a federal requirement under the Medicaid Drug Rebate Program states cannot exclude FDA-approved diabetes drugs from their formularies

doi: 10.3390/PH17020147

About 26% of the metformin and 14% of the placebo groups had lost greater than or equal to 5% of their initial body weight at the end of year two

doi: 10.2337/diab.43.4.535

Alcohol interactions also deserve mention

Disordered gastric emptying: mechanical basis, assessment and treatment
