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Gallbladder events at 1.4% are worth contextualizing

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Clinical evidence shows LDL reductions of 510% and triglyceride improvements of 1525% in most patients, with better results in those who achieve significant weight loss

Similarly, dark-colored urine (resembling tea or cola) or pale, clay-colored stools suggest altered bilirubin metabolism warranting investigation

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Limitations This was an observational study using electronic health records, which cannot establish causation and may suffer from diagnostic inaccuracies, unmeasured confounders, and selection bias