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In all cases, treatment plans need to be continuously reviewed for efficacy, side effects (including hypoglycemia), and treatment burden ( Table 9.2 )

Webster et al 15 analyzed data from patients in controlled clinical trials who achieved a clinicians rating of clear and compared it to that from patients who were rated almost clear. In these trials, a total of 1,366 subjects were treated with ivermectin, metronidazole, or vehicle

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Notably, patients with a BMI 35 kg/m 2 experienced greater benefits than those with lower BMI, potentially underscoring the benefit derived from targeting obesity-related metabolic drivers of heart failure rather than modulation of myocardial loading or neurohormonal mediation [118, 121]

Conversely, untreated hypothyroidism may reduce insulin needs
