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In AD, along with amyloid and tau phosphorylation, there is an associated increase in inflammation/glial activation, a decrease in synaptic function, an increase in astrocyte activation, and a state of insulin resistance
Although central activity is likely to contribute to visceral hypersensitivity, peripheral factors, including immune, paracrine and endocrine molecules, are also likely to play a role in the sensitisation of gut-to-brain signalling in IBS
In 2024, a study led by Dr
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In the STEP 1 trial, about 10% of participants achieved less than 5% weight loss, roughly the same as placebo response
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