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This review examines the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on different heart failure phenotypes with preserved ejection fraction

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GLP-1 receptor agonists improve MASH mostly via extrahepatic actions: 1 CNS appetite control weight loss systemic inflammation 2 Chylomicron synthesis & improve lipid metabolism 3 Bind gut immune cells anti-inflammatory + microbiome benefits 4 Reduce adipose & pancreatic inflammation

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Prebiotic supports digestive health and regularity extends GLP-1 lifespan for prolonged effects on glucose regulation and hunger suppression.*

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** **: GLP-1R (PDB ID: 4ZGM)

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Today, Business Insider features Gala, highlighting us as the leading GLP-1 platform in the US

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Participants The study included over 1.2 million T2DM patients who were prescribed anti-diabetic medications, including 181,795 prescribed GLP-1RAs between April 2013 and April 2019

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