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Proteolytically stable foldamer mimics of host-defense peptides with protective activities in a murine model of bacterial infection

Here, we find that semaglutide engages both G s and G q -dependent signalling pathways in Glp1r -expressing neurons in the area postrema (AP Glp1r ), the primary site of semaglutide action in the brain, and differentially regulates neuronal activation across distinct neuronal clusters

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"Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials"

Front Oncol

Thus, the clinical benefits for the risk of heart failure and kidney outcomes, except albuminuria, are likely to be a strength of SGLT2is, whereas those for the risk of stroke are a strength of GLP-1RAs (Graphical Abstract)