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The fast flow of food further helps to wash away bacteria before they get a chance to stick around

Health specialists emphasize that while these medications can improve metabolic health, they are not recommended during pregnancy or when actively trying to conceive

And retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, has shown even greater weight loss than tirzepatide in early trials

Darwesh AM, El-Azab MF, Abo-Gresha NM, El-Sayed NM, Moustafa YM

Like GLP-1, GIP travels through your bloodstream and activates specific GIP receptors in various organs

A meta-regression study suggested a linear relationship between HbA1c reduction and MACE risk in patient with arGLP-1.89 Publication on mediation analyses also suggest that cardiovascular benefit could be mediated in part by effects on HbA1c, on blood pressure or reduction in urine albumin-creatinine ratio90,91 (see below), as well as by their effect on lipid profile.81 However, in subgroup analyses of cardiovascular safety studies, baseline HbA1c, weight, previous cardiovascular disease, or renal function did not predict the beneficial effects of these drugs on MACE,87 so other mechanisms, such as the previously mentioned anti-inflammatory, antifibrotic, antiatherogenic, vasodilator, or endothelial function-enhancing effects, have been suggested to influence the cardiovascular benefit of these drugs29,78 (Fig