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Conclusions We demonstrated that TIR can ameliorate high glucose-induced neurodegeneration and overcome neuronal insulin resistance

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As the interest in incretin-based therapies has risen substantially, we discuss how incretin-based therapies, including glucagon-like peptide-1 (GLP-1) receptor agonists and GLP-1 receptor agonists and glucose-dependent insulinotropic polypeptide (GIP) dual agonists, might improve reproductive function and could interact with the physiological metabolic changes ensuring a healthy pregnancy

For those who want to go deeper: JAMA Psychiatry (2025):- GLP-1 RAs & Mental Health Meta-Analysis: JAMA Psychiatry (2025):- Semaglutide & Alcohol Use Disorder RCT: eClinicalMedicine / The Lancet (2024):- 12-Month Neurological & Psychiatric Outcomes of Semaglutide: APA Monitor (2025):- Mental Health Effects of GLP-1 Drugs (accessible overview):

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