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It is particularly suited to people who do not have insurance coverage for weight loss medications and are looking for a flexible, affordable monthly option

What the clinical trials tell us indirectly The SURMOUNT clinical trial program provides indirect evidence that lower doses can be effective

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If youre starting at the recommended 0.25 mg dose, its completely normal not to notice any dramatic changes

The cycling approach lacks strong clinical evidence but persists in practice because some patients report that it helps maintain effectiveness over a longer period

Side effects include the following: Drowsiness, dizziness, and nausea Loss of appetite and constipation Headache Muscle weakness Dry nose and throat Vision problems Short-term memory loss Difficulty with urination The FDA warns that prolonged exposure to diphenhydramine causes heart problems and seizures