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The FDA has issued warnings about unapproved GLP-1 drugs circulating online - counterfeit, compounded, or mislabeled as research use only. When access to legitimate GLP-1 clinical trials is limited - by geography, logistics, or site capacity - progress slows

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In fact, the majority of patients showed stable weight or continued weight loss after their last documented GLP-1RA prescription in the participating health systems.Notably, LLM-enabled curation of clinical notes revealed that patients without weight regain were significantly more likely to have documented exercise counseling after their last prescription, suggesting that continued physical activity may play a role in sustaining weight loss after GLP-1RA discontinuation