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Patients should report persistent stool changes to their GP, particularly if accompanied by abdominal pain, as GLP-1 therapy carries rare risks of pancreatitis and gallbladder disease

Additionally, a recent open-label randomized trial showed that semaglutide significantly reduced serum IL-6 and CRP levels in PsO T2DM patients, compared to controls not on semaglutide therapy, reinforcing the anti-inflammatory effects of GLP-1RAs (45)

Genetics, baseline insulin resistance, and lifestyle patterns influence outcomes

notably, subgroup analyses of placebo-controlled trials demonstrated a significant reduction in both colorectal and overall cancer risk [10]

doi: 10.1007/s004310000633 70 GastonLSStaffordDE

Brown JD, Buscemi J, Milsom V, Malcolm R, ONeil PM