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doi: 10.1074/jbc.M900166200

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On the other hand, there are also some real significant and potentially dangerous side effects that surfaced in clinical trials

As opposed to the small population of GLP1-expressing endocrine cells, the fact that a large part of the pancreatic acinar population expresses GLP1R, even in low density, indicates that there is a considerable amount of nonendocrine GLP1R in the pancreas, for which a physiological role is not yet known

In the chronic stage, M1 macrophages exist for a long time and mediate chronic inflammation with mature lymphocytes (Schwab et al., 2014)