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The study results, published in the July 15, 2026, online edition of The Lancet Gastroenterology & Hepatology, address a major unmet need for people with metabolic dysfunctionassociated steatohepatitis (MASH), a serious form of fatty liver disease that can lead to cirrhosis, liver failure, and the need for transplantation

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8 If youre still losing weight on Mounjaro or the higher 7.2 mg Wegovy injection, switching to the pill would likely mean less weight loss, so theres usually little reason to switch if youre losing weight sustainably on the injections

This change reflected growing evidence that metformin could be used safely in mild-to-moderate CKD with appropriate dose adjustments

Diet quality accelerates visible outcomes