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The trial showed that Patients under Exentide treatment showed decrease in both systolic and diastolic blood pressure average decrease in systolic pressure by -3.5 mmHg and by -3.3 in diastolic blood pressures

Consistent with this, GLP-1R agonism decreases a variety of reward behaviors in rodents, including the motivation to lever press for food reward in an operant conditioning test [746], alcohol intake [747,748], alcohol seeking behavior [747], amphetamine-induced conditioned place preference (Amp-CPP) [748], and hedonic feeding [748]

As Dr Al-Aly put it, Biology is too complex. More and more research is starting to emerge suggesting that GLP-1RAs could have a host of other medical uses

3 Patients on GLP-1s had a median HbA1c reduction of 0.5 points, while those on metformin had a median HbA1c reduction of 0.1 points

This mechanism differs from the caloric deficit fatigue described above

The glucagon component introduces a nuance absent from semaglutide and tirzepatide: mild elevations in blood glucose, particularly at the beginning of treatment