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Recent advancements in sustained-release formulations, like PLGA nanoparticles for delivering exendin-4, show promise in preclinical models but still require validation in human studies ( 4.3 Synergy with existing therapies Given the promising potential of GLP-1RA in ocular therapeutics, combing it with other current medicine could shed light on novel therapeutic approaches

Experts classify GLP-1 receptor agonists into two types: human GLP-1 backbone agents (e.g., Liraglutide, Dulaglutide, Semaglutide) and exendin-4 backbone agents (e.g., exenatide) (23)

However, caution is still advised

Gandhi A, Khanam V, Peterson D, Patel F, Kulairi Z

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doi:10.1007/s00125-002-0878-6 37