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Various GLP-1RAs have been demonstrated to have significant benefits in in vitro and in vivo models of neurodegenerative diseases through modulating a variety of pathogenic mechanisms, including neuroinflammation, autophagy, mitochondrial dysfunction, and the abnormal phosphorylation of pathognomonic proteins

They work by mimicking the effects of the naturally occurring hormone called glucagon-like peptide-1 (GLP-1), which is responsible for regulating insulin and blood sugar levels

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Fractyl Health has announced positive 6-month results from its open-label REVEAL-1 Cohort

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