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Quast, D., Schenker, N., Menge, B., Nauck, M., Kapitza, C., Meier, J

5052 There is also accumulating pre-clinical evidence that GLP-1 and GLP-1RAs may modulate several dysregulated inflammatory pathways and immune cell lineages relevant to IBD, although some findings derive from studies in non-intestinal epithelial or immune cell lineages

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Regulatory agencies may need to consider populationspecific monitoring recommendations as the use of GLP1RAs continues to expand

Tolerance often depends on dose, how quickly doses are increased, and personal sensitivity

These findings provide evidence that the generation of an intracellular source of cAMP is involved in GLP-1mediated cardioprotection