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its a protective mechanism where metabolism slows and hunger hormones change (often called metabolic adaptation) [utswmed.org]
10.1172/jci.insight.94263 85 StergiouC.LazaridisK.ZouvelouV.TzartosJ.MantegazzaR.AntozziC.et al (2016)

Am J Public Health 2014;104(Suppl 4):S517S519

A major advancement in diabetes treatment was achieved with the development of glucagon-like peptide-1 receptor agonists (GLP-1RAs)

The maximum dose of semaglutide used for the treatment of obesity is 2.8 mg/week (0.4 mg/day), whereas the maximum dose for the treatment of T2DM is 1 mg/week

Is SLU-PP-332 orally bioavailable