glp-1/gip/glucagon triple agonist LY3437943, a novel glucagon, GIP, and GLP-1 receptor for glycemic control and weight loss: From discovery to clinical proof of concept: Cell Metabolism Beyond GLP-1: Retatrutide's triple-agonist mechanism
Description
In GIPR, Q138 1.40b and two glutamic acid residues (E135 1.37b and E288 45.52b ) make three hydrogen bonds with Y10 P and T7 P , while F22 P and MeL13 P /L14 P in retatrutide interact with Y36 ECD and R131 1.33b through stacking and hydrophobic contacts, respectively
Insights may cover the historical clinical development of Glucagon-like Peptide-1 (GLP-1) Agonists, their mechanism of action, their subtypes and future commercial prospects
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While this hasnt been definitively proven in studies, the theoretical risk exists
Urva S, et al
