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Clinical trials of brand-name tirzepatide showed up to 22.5% body weight reduction at the highest dose plus improved cardiovascular and metabolic markers those studies inform how the active ingredient is understood, but the safety, efficacy, and quality data from those trials do not directly apply to compounded preparations

Springer Publishing Company, 2021

Combination therapies should be offered as a first line of treatment and not as a last resort for patients with severe and complex obesity

The higher the concentration, the more each unit matters

In addition, patients with HF can have their cardiac function and prognosis assessed using 6MWT, NT-proBNP, and QoL [51]