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These medications can be helpful in patients: with a diagnosis of type 2 diabetes who would benefit from weight loss who have certain severe weight-related conditions

With more than 100 active GLP-1 clinical programmes worldwide, the bar for differentiation is rising rapidly

Do I need to make lifestyle changes

August 2025 : The US FDA approved Wegovy (semaglutide 2.4 mg) for the treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis), in combination with a reduced-calorie diet and increased physical activity

Furthermore, as your body begins to burn through stored glycogen (the way your body stores carbohydrates), it releases a significant amount of water

Lee et al., 2015
