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Worsening reflux or GERD Some people report heartburn or reflux-like symptoms when using GLP-1 medications

Footnotes This article contains Supplementary Data online at This publication is based on the presentations from the 4th World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)

However, patients with severe renal impairment, type 1 diabetes, or recent pancreatitis should not use GLP-1 medications

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These positive effects on weight loss together with the experimental evidence suggesting that liraglutide exerts its effects directly in the CNS raise the question of whether GLP-1RAs of higher molecular weights, such as dulaglutide and albiglutide, would be as effective as liraglutide in promoting weight loss [23]

The finding also could explain the observation that people who take GLP-1 agonists tend to reduce their consumption of alcohol.