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Reason being, dihydroberberine is naturally made in the human digestive tract as a berberine metabolite -- it's produced when the gut microbiome hydrogenates berberine so that it can absorb it

One study noted a potential increased risk of kidney cancer in people taking the drugs

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[DOI] [PubMed] [Google Scholar] 49.Drucker DJ, Philippe J, Jepeal L, Habener JF

Evidence of such side effects was evident in our latest analysis of brands to watch in 2024, where both Ducolax and Miralax made the list of fastest-growing brands among GLP-1 users in 2023
