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*Correspondence: Lishou Xiong, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The headline figure stopped people in their tracks: participants on the 12 mg dose lost an average of 28.3% of their body weight at 80 weeks

Professor Mollan reports other Invex Therapeutics, other Heidelberg engineering during the conduct of the study

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Finally, in the light of the high incidence of hypoglycemia unawareness and the low sensitivity of symptoms to hypoglycemia, it was recently suggested that the presence of neuroglycopenic symptoms may disappear over time and should therefore not be a requirement to diagnose PBH (5)