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Description
DPP-4 inhibitors which increase levels of GLP-1, a hormone that helps reduce blood sugar levels have been approved for treatment of type 2 diabetes since 2006

The anti-apoptotic functions of GIP are largely mediated by the PKA-dependent phosphorylation of CREB, whilst the influence of GLP-1 on apoptosis requires PI3K [101, 104]
Vakalopoulos C

GLP-1s increased the release of insulin but had an extremely short half-life (one to two minutes), making them highly unfavorable as a treatment for diabetes

If nausea remains severe at this point, discuss with your provider before advancing doses
Cardiovascular Safety Studies With DPP-4 Inhibitors The Clinical Guidance for Pharmaceutical IndustryDiabetes MellitusEvaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes established by the FDA in 2008 as a consequence of adverse safety signals of rosiglitazone has set up the requirement for novel diabetes medications to prove cardiovascular safety of these substances in comparison to standard therapy under glycaemic equipoise
