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Por meio da ao sobre PPAR-gama, so drogas que promovem maior sensibilidade insulina no msculo perifrico e reduo da produo heptica de glicose, alm de inibio da liplise perifrica em adipcitos, reduo dos nveis de cidos graxos livres e da adiposidade visceral, resultando em melhora de parmetros glicmicos e metablicos nesses pacientes
Wilding JPH, Kwan AYM, Maldonado JM, Wang H, Rasouli N (2022) Tirzepatide induces weight loss in patients with type 2 diabetes regardless of baseline BMI: a post hoc analysis of SURPASS-1 through SURPASS-5 studies
Bouret & Simerly, 2004 )

In addition, the estradiol and progesterone secretion were stimulated, and the number of Graafian follicles and corpora lutea were increased along the estrous cycle [35]