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The recent conclusion of major phase 3 trials for the oral glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide represents another notable setback in this endeavor ( The observed discrepancy between promising preclinical and epidemiological data and the negative outcomes of a large-scale clinical trial in established Alzheimers disease (AD) necessitates a thorough analysis

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In India it is used for type 2 diabetes and, in selected patients, for medically supervised weight management

| 1 Youre not in a calorie deficit | 2 Youre in a weight-loss plateau | 3 Your current dose isnt high enough to promote lower hunger | Practical strategies | Frequently asked questions | Take home message The main reasons youre not losing weight on semaglutide (Wegovy/Ozempic) might be that youre not eating in a calorie deficit, youve hit a weight-loss plateau, or the current dose that youre on isnt high enough to lower your hunger to the point where youre eating less

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