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P =0.15, high certainty of evidence), insulin (RR, 0.89

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The suppression of the NLRP3 inflammasome and the promotion of an M2 phenotype in macrophages (Section 2.3) directly translates into more stable atherosclerotic plaques with a reduced inflammatory burden (Section 2.1) [29,43]

IECs-associated inflammasomes like NLRP6 are critical for mucosal homeostasis and infection defense (216)

Cells were cultured at 37 C in Dulbeccos modified Eagles medium (DMEM) + GlutaMax 1965 (Gibco) supplemented with 10% fetal bovine serum and 1% penicillinstreptomycin in a humidified 10% CO 2 incubator