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The popularity of GLP-1 agonists to treat obesity has been skyrocketing in recent months, leading to both shortages and price increases

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The availability of efficacy data in the SUSTAIN FORTE metforminonly population allowed for an indirect comparison in the primary analysis in patients receiving the same background antihyperglycaemic medication in both trials

These delayed adjustments have created a predictable enforcement wave, led not by the FDA, but by state attorneys general

Moreover, the observation that adding GLP-1MK-801 treatment on top of semaglutide leads to an additional weight loss of 7% in mice that have reached a weight loss plateau with semaglutide provides additional support for integrating NMDA receptor antagonism in next-generation weight loss therapeutics