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Semaglutide was dosed for the full period, while antibody dosing with the -MSTN and -ActA antibodies was started in Week 2 as an add-on to semaglutide and dosed through Week 12 (and was presumed to have more durable actions due to the extended half-life of the antibodies)

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A Note About Rapid Weight Loss Very rapid weight loss can increase fatigue, raise the risk of gallstones, and potentially reduce milk supply

Tirzepatide, a newer dual GLP-1/GIP receptor agonist, demonstrated even larger reductions in some studies, with systolic decreases reaching 68 mmHg in overweight patients

After culturing for 2 h, the medium was replaced with CO 2 - independent equilibration medium (Life Technologies Co, Carlsbad, CA) containing 6% v/v GloSensor cAMP reagent (Promega) and 0.1% BSA according to the manufacturers instructions

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